Treating C. difficile
نویسندگان
چکیده
منابع مشابه
There is a trend favoring vancomycin vs. metronidazole in treating severe C. difficile infection
A critical appraisal and clinical application of Johnson S, Louie TJ, Gerding DN, et al. Vancomycin, metronidazole, or tolevamer for Clostridium difficile infection: results from two multinational, randomized, controlled trials. Clin Infect Dis. 2014;59(3):345-354. doi: 10.1093/cid/ciu313
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Clostridium difficile is the most important cause of nosocomial diarrhea. Several laboratory techniques are available to detect C. difficile toxins or the genes that encode them in fecal samples. We evaluated the Xpert C. difficile and Xpert C. difficile/Epi (Cepheid, CA) that detect the toxin B gene (tcdB) and tcdB, cdt, and a deletion in tcdC associated with the 027/NAP1/BI strain, respective...
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The prevalence of Clostridium difficile infections in HIV-positive patients with regard to the presence of its enterotoxin was investigated. Enzyme immunoassay (EIA, Meridian Diagnostic Inc) was used for the detection of C. difficile enterotoxin in stool specimens collected from 201 HIV-positive and 271 HIV-negative diarrheal patients. Culture was performed on cycloserine cefoxitin fructose aga...
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LEVEL OF RECOMMENDATION DEFINITIONS Level 1: Convincingly justifiable based on available scientific information alone. Usually based on Class I data or strong Class II evidence if randomized testing is inappropriate. Conversely, low quality or contradictory Class I data may be insufficient to support a Level I recommendation. Level 2: Reasonably justifiable based on available scientific evi...
متن کاملClostridium difficile toxins and severe C. difficile infection.
The pathogenesis of colitis due to Clostridium difficile is closely linked to the elaboration of 2 large, single-unit glucosyltransferases referred to as toxin A (TcdA) and toxin B (TcdB). Clinical isolates from patients with symptomatic C. difficile infection (CDI) invariably produce both TcdA and TcdB or TcdB alone. Vaccination of experimental hamsters against both toxins prevents fatal C. di...
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ژورنال
عنوان ژورنال: Canadian Medical Association Journal
سال: 2005
ISSN: 0820-3946,1488-2329
DOI: 10.1503/cmaj.1041461